The preparation of a patient’s skin before surgery is a critical step in reducing the risk of surgical site infections (SSIs), which are among the most common postoperative complications. When combined with sterile techniques, proper skin preparation helps to minimize the microbial load on the skin, thereby preventing pathogens from entering the surgical site. SSIs can lead to increased healthcare costs, prolonged hospital stays, and significant patient morbidity. Sterile technique—encompassing practices such as hand hygiene, sterile draping, and appropriate antiseptic application—is essential in maintaining a controlled environment free of harmful microorganisms. Preoperative skin preparation is particularly important as it aims to remove transient microorganisms and reduce resident flora to levels that are no longer pathogenic.
There are various protocols available for preoperative patient skin preparation, and the appropriate selection depends on factors such as the surgical site, patient sensitivities, and type of procedure. Two commonly used protocols are chlorhexidine-alcohol and povidone-iodine solutions. Chlorhexidine-alcohol, a combination of 2% chlorhexidine gluconate and 70% isopropyl alcohol, is widely recommended due to its broad-spectrum antimicrobial activity and prolonged residual effect. It is effective against both gram-positive and gram-negative bacteria, making it suitable for a wide range of surgeries. Povidone-iodine is another widely used antiseptic, particularly for patients sensitive to chlorhexidine or for procedures near mucous membranes. It offers broad antimicrobial coverage but has a shorter residual effect compared to chlorhexidine. Preoperative protocols may also include patient cleansing with chlorhexidine-based wipes or solutions at home before surgery, further reducing microbial load on the skin.
The step-by-step technique for surgical skin preparation involves a systematic approach to ensure thorough antisepsis of the surgical site. First, the healthcare provider assesses the patient and surgical site to select the appropriate antiseptic solution. They then don sterile gloves to maintain aseptic technique throughout the process. The prep begins at the planned incision site and moves outward in an ever-widening circular motion, covering an area larger than the anticipated surgical field. For alcohol-based solutions, the skin is gently wiped following the manufacturer’s instructions, typically using a back-and-forth motion for the prescribed time based on the body location. It’s crucial to allow the solution adequate drying time, which can range from three minutes on hairless skin to up to an hour in hair for alcohol-based products. Once dry, sterile drapes are applied to isolate the prepped area. For procedures involving multiple sites, such as grafts or abdominal-perineal surgeries, separate prep set-ups are used for each area to prevent cross-contamination. Throughout the process, care is taken to avoid touching non-sterile items and to prevent the accumulation of prep solution, which could lead to chemical burns. After patient skin preparation is complete, the surgical team maintains vigilance to ensure the sterile field remains intact until the wound is sealed and dressed.
The effectiveness of these disinfectants is due to their mechanisms of action. Chlorhexidine disrupts bacterial cell membranes, causing leakage of cellular contents and leading to cell death. It is highly effective against gram-positive bacteria like Staphylococcus aureus and gram-negative bacteria like Escherichia coli, though it has limited efficacy against fungi and viruses. Alcohol, often used in combination with other agents, works by denaturing proteins and rapidly killing microorganisms upon contact. Povidone-iodine penetrates microbial cell walls and disrupts metabolic pathways, making it effective against a wide range of bacteria, fungi, and some viruses.
Evidence from clinical studies highlights the importance of selecting appropriate skin prep solutions to reduce SSIs. For example, a systematic review found that 2–2.5% chlorhexidine in alcohol significantly reduced SSI rates compared to aqueous iodine solutions (relative risk 0.75). Another study demonstrated that chlorhexidine-alcohol outperformed povidone-iodine in bacterial eradication during foot and ankle surgeries. These findings underscore the importance of evidence-based practices when choosing antiseptic agents for preoperative skin preparation. By tailoring protocols to specific needs—such as anatomical location or patient sensitivities—healthcare providers can optimize outcomes and reduce the risk of SSIs.
In conclusion, patient skin preparation protocols are a cornerstone of infection prevention in surgical settings. Adherence to sterile techniques and the use of effective disinfectants tailored to individual circumstances can significantly lower the incidence of SSIs. As research continues to refine these protocols, healthcare providers have more evidence-based tools at their disposal to ensure safer surgical outcomes.
References
- AORN Outpatient Surgery Magazine. The Essentials: Peerless Skin Prep: Here’s How. July 2023. DOI: https://www.aorn.org/outpatient-surgery/article/the-essentials-peerless-skin-prep-here-s-how
- American Academy of Orthopaedic Surgeons (AAOS). Surgical Site Preparation Toolkit. Accessed February 2025. DOI: https://www.aaos.org/quality/quality-programs/quality-toolkits/surgical-site-preparation/
- Outpatient Surgery Magazine. Your Updated Guide to Surgical Skin Preps. November 2022. DOI: https://www.aorn.org/outpatient-surgery/article/2010-May-your-updated-guide-to-surgical-skin-preps
- PubMed Central (PMC). A Systematic Review on Skin Preparation Solutions for SSI Prevention. August 2022. DOI: https://pubmed.ncbi.nlm.nih.gov/35985350/
- Centers for Disease Control and Prevention (CDC). Chemical Disinfectants. November 2023. DOI: https://www.cdc.gov/infection-control/hcp/disinfection-sterilization/chemical-disinfectants.html